120780

@120780 (16)

India • Age 44

Joined myLot 18 years ago

Discussions (1)

Comments (3)

120780's Comments

Amphoteric drug absorption and pKa

120780 @120780 (16) • India 20 Sep 06

One question in my mind is; how can we predict the ionized and unionized part of amphoteric drug at different pH level of gastrointestine

absorption of amphoteric drug

2 responses

120780 wrong, unionized drug has good permeablity

11 Oct 06

Amphoteric drug absorption and pKa

120780 @120780 (16) • India 20 Sep 06

One question in my mind is; how can we predict the ionized and unionized part of amphoteric drug at different pH level of gastrointestine

2 responses

120780 how permeability is not a problem?

7 Oct 06

Amphoteric drug absorption and pKa

120780 @120780 (16) • India 20 Sep 06

One question in my mind is; how can we predict the ionized and unionized part of amphoteric drug at different pH level of gastrointestine

2 responses

120780 Hi, I agree with your response that the equation PH=pKa+Log(salt/acid)can helt in determining ionized and unionized part of drugs. I know this is a Handerson Hesselbatch equation. This is true when the drug is weakly acidic and weakly basic then this equation...

5 Oct 06