adjusting to new job environment

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once you take up new employment do you regret your decision in first few days? how much time it take for adjusting? Do you feel like going back to previous work environment? I do feel like this always. have changed job 4 times in last 6 years but still not able to adjust to teh new environment quickly. Is there any problem with me or is this a same to everybody? any technique of overcoming this...