HELP: Is there such a thing as allergic to anti-allergy drugs?

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While working in the graveyard shift a few years back, I had an 'outbreak' of rashes all over my face. It started as a small patch that was so itchy I went to the clinic to ask for oral medication. I was given anti-histamine (I forgot the brand name) but less than hour after I've taken it, my face got all red and even my chest, back and stomach got all itchy I was advised to take a rest and wait for the medication to take effect. I ended up being taken to the emergency and they injected me with something that was supposed to solve the problem. I fell to a deep sleep and when I woke up around 6 hours later, the rashes were all gone. They said it was 'just' an allergic reaction to the elements (smoke and stress) in the workplace. I have mitral valve prolapse (MVP) and I'm researching whether such allergic reaction could be attributable to my MVP or if it's the other way around...or if it is simply an allergy to a certain brand of anti-allergy drug. Anyone here who could care to enlighten me?