How did you or do you handle the TERRIBLE 2's

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I have 4 children, my first two I never had a problem with them having what they call terrible 2's, one is now 15 and the other is 3 1/2. My third child is 2 1/2 and OH MY GOD! now I know what people where talking about when they say terrible 2's, she says no when asked to pick up her toys, and if I start to pick them up myself after asking several times she will start SCREAMING and kicking and times she even throws herself to the floor. I have tired the time out, putting her on her booster seat and making her sit for a few minutes, I have tried putting her in the corner, putting her upstairs in her bedroom, and everything I try she just Screams to the top of her lungs, some of her screams actually sounds like she is being hurt. How did you handle the terrible 2's?