Rebel niece...

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I have a niece who's so dear to me, her parents separated for almost a couple of years by now since then i observe that her attitude change, she stop schooling, flirting lots of guys, wearing short dress, not respecting even her self she don't act like that before..I really try to reach her now but she refuse, now i heard she run away from their house, How can i help this child? please give some advice her mother has her own family just like his father now. I loved her and i care for her, i don't wanna see her wasting her life for nothing.. hope to hear you good advice?