Signs a guys not interested

I bet if he is not the usual guy you used to know, meaning he was totally a stranger in your eyes. He doesn't act the way he used to be, he seldoms see you, seldom call you, seldom do the usual things you do and even refuse you for some things you ask him. Make excuses when he refuses to your invitations as well, and get easily irritated to anything. I supposed those were the signs.