What do you think is the hardest thing for a woman to have to give up?

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I think the hardest thing for a woman to give up is children, even the ability to conceive. Almost every woman looks forward to having children. Whether its a boy that looks just like his father or a daughter that looks just like her mother. Sometimes relationships become strained and can be devastating when a woman can not conceive. Also, losing a child through death can be devastating as well. Some people never get over it. What do you think?