What is this feeling?

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...I'm curious... does anyone ever have the feeling of--for lack of a better word--doom... for an extended period of time? That is to say, do you ever get the self concious feeling of everything being out of sorts (or one specific thing that you simply can't put your finger on), and you don't know why, or how to change it? Did it go away eventually? Did you do anything in particular to change the way you felt, or eventually figure it out?