A new serie's, with a different cast?

I think it ran its course and did pretty well. If they tried to do it again but with a different cast then they'd need to have significantly different storylines and characters as well - and by that point it's just not the same show! It can be sad to let go of a show you loved but there will always be new things taking its place, and it's better to quit while you're ahead than try to squeeze every last breathe out of a concept.

Honestly wouldnt be friends heh.. What made friends was the characters and the actors. I hate when actors get switched out once i associate them with a character, cause then it's just not the same anymore. Making a new show with diffrent actors would be milking the show and i would not see it becoming popular, except maybe from new viewers.

Like Guiltypleasure say: Friends without same characters is not Friends.

I don't know, friends with a different cast wouldn't be friends. The original cast is unmatched.

They might as well change name. Each and every character in the series has been done justice by the actors who play them. It wouldn't be right to change the cast.