When others say, "it's not meant to be". Do you still pursue for it?

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I have heard that many times in different scenarios, to me I consider that as an emphatic word from a friend whose intention is to uplift me in a certain degree. Unfortunately, it does not serve me well. Instead, I put to mind these words and become optimistic, pick up the pieces and try again. I don't give up, I always prove to myself that one can change his/her destiny only if he persists and make things happened in different course. There are a lot of ways if you want it, and a lot of reasons if you don't want it. What's your side? :)