In-laws are sick, they kept on telling me but they don't listen to me...

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I am really bothered with my in-laws. My mother-in-law is highblood but doesn't want to drink her medicines regularly. Whenever she reach 160/100 or above it, I asked her to put a Captopril under her tongue, she always resisted but the good thing is I still could manage her to follow. But there is one thing that really bothers me a lot... she was bleeding. She told me and I saw her undies having blood, not just stain but real blood. I told her that I will accompany her to the doctor but she doesn't want to go. I told my husband but still she never listen. My husband told her older sister who is based in the U.S., and my sister in law calls her and lectures her, but she still is not listening. She told us that she knows herself more than anybody else, she can handles herself perfectly well than any other doctor. That's how tough she is. But I worry more, because her bp drops significantly and her weight too. My office mates and friends are telling me that the worst case could be colon cancer but I do hope it is only a kidney stone. My father-in-law tested her sugar too yesterday and it turn outs to be 140 while the normal is only 106 i think. We are also asking them for a check-up but hardheaded that he was, he doesn't want to go. He just surpassed a mild heart attack after her operation and we doesn't want him to experience it again. A high sugar could trigger a high blood pressure. People are saying that it is harder to take care of an old man rather than an infant. Now I know it is true. How do you handle it if you are in my situation?