Makes Humans

Well actually, every mammal, animal, reptiles, and humans have heart, brain, and desire. But to answer your question, what truly makes people humans is our reasoning. We are the only creature in earth who has the ability to reason. Others, they do not. Reasoning is what makes us human since we all have that, yes, even the mentally retarded people have reasoning although it is flawed. I hope i helped. :D Cheers~