When Is It Time to Cut Off Advice to a Family Member?

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So, my younger brother called a couple days ago drunk, talking crap and asking for my opinion. I didn't sound like he wanted my opinion but sifting through his snide remarks I asked him what his true intention for calling was. He broke up with his girlfriend. She kicked up him out over her dad who is staying with them temporarily. I know, not a good idea to invite any family to live with you. Been there, done that. I told him that. Well, push came to shove and he gave her an ultimatum, him or me. I told him, "You shouldn't have done that. There are better ways to handle this." His intoxication didn't help the situation, another thing I brought to his attention. After nearly two hours talking on the phone, he walked away with I presume no plan and heeding none of my advice. How do I know? I text him a day later asking him what he did and his response was, "With what?" Argh. I know you good people deal with and have dealt with a family member who refused(s) to heed your advice, but my question is, do you keep trying to help them? If not, at what point do you say enough is enough?