5% to 10% of adult patients have Type 2 diabetes - caused by insulin resistance

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Insulin resistance is the main cause of diabetes type 1 and also diabetes type 2. Type 1 diabetes mellitus results from immune-mediated destruction of pancreatic very little beta cells. Most commonly affected children and adolescents present with symptoms of hyperglycemia including polyuria and weight loss. Moreover in few cases coma. It is important to remember Type 1 diabetes mellitus can occur at any age. It is estimate that approximately 5% to 10% of adult patients have Type 2 diabetes mellitus and caused by insulin resistance. Almost 90% of type 1 diabetic new cases occur without a family history of type 1 diabetes mellitus. However relative of patients with type 1 diabetes have a 100% increased risk of developing type 1 diabetes mellitus. These are the common causes of type 1 diabetes mellitus. Insulin resistance as a result in glucose overproduction Insulin resistance is the main cause of type 2 diabetes mellitus. Patients with type 2 diabetes mellitus share a pathophysiology that involves the pancreatic beta calls, the liver and skeleton muscles and some tissue. In addition variable degree of beta cell dysfunction is present in these patients in addition to hepatic insulin resistance and as a result in glucose overproduction. Approximately 70% to 80% of the glucose produce by the liver and use by the brain. Insulin resistance is present in 90% of patients with type 2 diabetes mellitus. Moreover the role of insulin resistance in the genesis of the metabolic syndrome remains controversial but there is a strong association. Glucose metabolism can be affecting a wide variety of cellular functions and signaling pathways. Hyperglycemia establish as a key factor in the development of diabetic microvascular disease affecting the retina and renal.