It can be very difficult to deal with someone who is deeply depressed

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I have a long time friend, she used to live close by me but now she is several hours away. I've known her for years. She had a bad first marriage, finally divorced him, and found a brand new husband in nothing flat. She seemed determined to find a man, and she did. Luckily, he is a really nice fellow and has the patience of a saint. She is making him crazy with all of her drama, her deep depression over everything in general, her kids/his kids, and so on. She finally lets one subject go and then starts on another one. This woman has several college degrees, one a Master's in teaching special ed, another a BSN in nursing. She is very book-smart. She has also fought severe depression for all of her adult life. It has definitely affected many of her personal relationships with friends and family. Until recently, I steered clear of her drama when it was at it's peak, as I, along with others, never knew what to say. Yes, she is bipolar and depressed. She is bossy and demanding. However, she can be so nice, is very compassionate, a good person...but...yes. But... A few weeks ago, I wrote about getting to unexpectedly go to my class reunion. I did not plan on going, didn't buy a ticket, just didn't think I could leave my son. But another friend decided I was going and she basically showed up and we found someone to help my son for a bit, threw my stuff in a suitcase, and off I went. This was not planned!!! This was in the town I used to live in, about 120 miles south of where I am now. Not a long trip. When I go there to visit, I always stay with my best friend at her house. I am always welcome and she was adamant that I stay with her during the reunion. I was invited and had some unexpected FUN. Not a crime, right? OH, my. My depressed friend discovered I went to my reunion. She used to live there, too. She is absolutely furious that I ''didn't include her!'' This was not HER reunion. She didn't go to school there, she married a guy from that town and moved there in her late 20's. I didn't live there at that time, I got to know her later when I moved back to the area. She is just so mad. She called me and told me I was selfish for not including her. I didn't even think of doing so--why would I? It wasn't HER reunion! She says I was mean and only thinking of myself. She was not invited. These were not even people she knew. But for some reason, she is furious that I stayed with my best friend, and went to my own reunion. She said I had completely ruined a long friendship. This is a woman who has been hospitalized many times for severe depression, has attempted suicide in the past, and just has a lot of issues. I have been her friend. She wants me to apologize for not inviting her to go with me (she lives 2 hours to the east, anyway!) and for staying with my friend. I have not called her. I don't want to. She is raging mad, not making sense, and hopefully her husband or adult children will take her to the hospital and she can get her meds stabilized again and get past this fit she is throwing. I can't fix it because it doesn't make any sense, and to be honest, I can't fix it anyway--it's' past fixing, I think. So, do I just keep on doing what I am doing now--not contacting her or doing the apology she has demanded? I don't mind apologizing if I am in the wrong, not at all. But, all I did was go to a reunion. It's been several weeks and I just can't make myself reach out to her, with her being so hateful. I know she is mentally ill, but I can't fix her. I've been her friend a long time, I've talked her through a lot of things, I've driven her to the hospital, visited her, taken meals, whatever. I usually never give up on people. This time, I have to. I have never thought about myself being a bad friend before, but she screamed at me that I was the worst friend in the world. Depressed or not, I think I am better off without her in my life. I can't help her and to be honest, I can't deal with all of it. What would you do?