Friendship ~ What really is the true meaning?

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My family and I were best friends/family with our neighbors for 7 years up until 4 months ago when they stopped talking to us after they had to give up their (under the table/cash) childcare. She (the wife) watched both my young sons at the time. We even gave them extra $ to help them get by. The husband works but is very sensative and gets pissed about every little thing you do or say wrong, he even went as far as to pull me aside as tell me my husband has an anger problem and needs to be on prozac. They are pill poppers, she's been on "happy" pills as long as I have known her. Still to this day we have no idea what we did wrong or what. How would you handle this situation? At this point we keep to ourselves especially since our children are invovled. They don't even talk to our kids or much less wave to them when they are riding their bikes in our cul-de-sac! What is wrong with people?