Is Middle Earth Natural?

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I am studying Geography at University and this week I have had a really fascinating lecture that has led me to start this thread which I hope will develop into some intriguing debate. I will give a bit of the background of this lecture first so you know what I am on about! This lecture was on Nature. The lecturer argued to use that little in our world today is in fact natural. We as humans do label many thing as being natural, for instance we label natural disasters as being natural things. We would also many of us see a cow in a field and think that that is natural. But those things are not natural. Almost everything today has been influenced to some extent by humans. Nature/ Natural is a socially contructed term, which we as humans apply to things. This has led me onto my question in the title of this thread. I got thinking, is there any place in Middle Earth that is truly natural. And by this I mean that has not been altered by humans. Also by humans I mean any race on Middle Earth. Lothlorien is not natural. The Shire is not natural. Mirkwood is not. Mordor is not. Gondor is not. The only place I could possibly think of is Fangorn. Few people venture in there and it does seem as though there are limited paths. However Fangorn forest as a whole cannot be classed as natural as we know Saruman has chopped down areas of it, thus influencing the growing patterns of the forest. So my question to you is: Are there any places in Middle Earth which are natural?