Don't know what you got, till it's gone

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So I just saw 2 1/2 Men... I just started watching that show so I have no idea what's going on... but there was this woman Rose... apparently she's Charlie's stalker... and everyone keeps telling him what a perfect woman she is. He denies it and refuses to give her a chance. She finally goes to him and tell him she's moving to London... he doesn't believe her until he goes by and sees her empty beach house. He suddenly realizes his mistake and sees that he let go of a smart beautiful woman who loved and adored him.... My whole point is, has anyone ever done that? Have you ever given someone up... or not given them a chance only to find out in the end, after it's too late, that you really messed up and should have taken it while you had the chance to?